Tirrell Lab

The Science of Self-Assembly
The Tirrell laboratory has broad and deep expertise in creating novel, functional self-assembled structures focusing on tailored nanomaterials for basic science research and therapeutic applications. In many cases our work has involved the specific design of new molecular architectures that showcase the fundamentals of self-assembly.

The capacity to create a variety of new structures is useful in designing constructs for diagnostic and therapeutic applications where nanoparticles are able to target and home to asymptomatic and resistant pathologies. One such construct is the micellar structure formed by electrostatic complexation of ionic block copolymers, which can be an effective carrier vehicle for charged cargoes such as therapeutic drugs, proteins or nucleic acids. We also have expertise in peptide-based micellar constructs where the dense presentation of a functional peptide at the micelle surface improves the interaction of our nanomaterials with cells. We have used these strategies to great effect as antimicrobial treatments, for the detection and treatment of atherosclerosis and cancer, in regenerative medicines, and also vaccines.

We are poised to both continue the development of new nanomaterials and to drive the use of these constructs as rapidly as possible towards clinical applications. To this end, we work closely with scientific, technical, and clinical collaborators both at the University of Chicago and elsewhere.

 

Principal Investigator

Matthew Tirrell

mtirrell@uchicago.edu

Effect of mixed solvents on polyelectrolyte complexes with salt

Meng, S., Liu, Y., Yeo, J., Ting, J. M., & Tirrell, M. V. Effect of mixed solvents on polyelectrolyte complexes with salt. Colloid and Polymer Science, 1-8.

Assembly and Characterization of Polyelectrolyte Complex Micelles

Marras, A. E., Vieregg, J. R., Tirrell, M. V. Assembly and Characterization of Polyelectrolyte Complex Micelles. J. Vis. Exp. (157), e60894, doi:10.3791/60894 (2020).

An in situ shearing x-ray measurement system for exploring structures and dynamics at the solid–liquid interface

Qiao, Yijun, Hua Zhou, Zhang Jiang, Qiming He, Shenglong Gan, Hongdong Wang, Shizhu Wen et al. "An in situ shearing x-ray measurement system for exploring structures and dynamics at the solid–liquid interface." Review of Scientific Instruments 91, no. 1 (2020): 013908. Harvard

Mechanism of Dissociation Kinetics in Polyelectrolyte Complex Micelles

Wu, Hao, Jeffrey M. Ting, and Matthew V. Tirrell. "Mechanism of Dissociation Kinetics in Polyelectrolyte Complex Micelles." Macromolecules (2019).

Hydrophobically assembled nanoparticles: Self-assembled nanoparticles

Wang, J., Mellas, M., Tirrell, M. and Chung, E.J., 2020. Hydrophobically assembled nanoparticles: Self-assembled nanoparticles. In Nanoparticles for Biomedical Applications (pp. 325-347). Elsevier.

Structure and dynamics of lipid membranes interacting with antivirulence end-phosphorylated polyethylene glycol block copolymers

Yu, J., Mao, J., Nagao, M., Bu, W., Lin, B., Hong, K., Jiang, Z., Liu, Y., Qian, S., Tirrell, M. and Chen, W., 2020. Structure and dynamics of lipid membranes interacting with antivirulence end-phosphorylated polyethylene glycol block copolymers. Soft Matter.

Amphiphilic Copolymer Inhibition of PNIPAM-PS Aggregation is HLB Dependent

Michelle X. Ling, Jeffrey M. Ting, Amanda B. Marciel, Matthew V. Tirrell, Raphael C. Lee, 2020. Amphiphilic Copolymer Inhibition of PNIPAM-PS Aggregation is HLB Dependent. Biophysical Journal 118 (3), 1992.

Enrichment and Distribution of Pb2+ Ions in Zwitterionic Poly(cysteine methacrylate) Brushes at the Solid–Liquid Interface

He, Qiming, Yijun Qiao, David J. Mandia, Shenglong Gan, Huiru Zhang, Hua Zhou, Jeffrey W. Elam, Seth B. Darling, Matthew V. Tirrell, and Wei Chen. "Enrichment and Distribution of Pb2+ Ions in Zwitterionic Poly (cysteine methacrylate) Brushes at the Solid-Liquid Interface." Langmuir (2019).

Preferential targeting of MCL-1 by a hydrocarbon-stapled BIM BH3 peptide

Hadji, Abbas, Greta K. Schmitt, Mathew R. Schnorenberg, Lauren Roach, Connie M. Hickey, Logan B. Leak, Matthew V. Tirrell, and James L. LaBelle. "Preferential targeting of MCL-1 by a hydrocarbon-stapled BIM BH3 peptide." Oncotarget 10, no. 58 (2019): 6219.

Integrating Systems Thinking into Teaching Emerging Technologies

Fowler, Whitney C., Jeffrey M. Ting, Siqi Meng, Lu Li, and Matthew V. Tirrell. "Integrating Systems Thinking into Teaching Emerging Technologies." Journal of Chemical Education (2019).

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Professor Juan J. de Pablo, Ph.D.

Professor Stuart Rowan, Ph.D.

Professor Yun Fang, Ph.D.

Professor James Labelle, M.D., Ph.D.