Mat Schnorenberg
Tirrell Group

Mathew Schnorenberg

  • Ph.D. Candidate
    MD-PhD Student

  • Contact: schnorenberg@uchicago.edu
  • Office Location:
    5640 South Ellis Avenue, Eckhardt Research Laboratory 108, Chicago, IL 60637

Mat Schnorenberg received his AB in biomedical engineering from Harvard University in 2014. He then came to the University of Chicago as an MD-PhD student. After completing his first year of medical school, he began his PhD in molecular engineering and is co-mentored by Professor Matthew Tirrell and Dr. James LaBelle.

Areas of research expertise:

  • Targeted nanoparticles
  • Drug delivery
  • Peptide therapeutics
  • Cancer biology

Mat's PhD work is aiming at combining the LaBelle group's peptide-based cancer therapeutics and the Tirrell group's micellar drug delivery system to rationally design a modular drug delivery system that protects the drug on its journey in the bloodstream, helps it find a specific cellular target, and enhances its efficacy at its subcellular molecular target.

Preferential targeting of MCL-1 by a hydrocarbon-stapled BIM BH3 peptide

Hadji, Abbas, Greta K. Schmitt, Mathew R. Schnorenberg, Lauren Roach, Connie M. Hickey, Logan B. Leak, Matthew V. Tirrell, and James L. LaBelle. "Preferential targeting of MCL-1 by a hydrocarbon-stapled BIM BH3 peptide." Oncotarget 10, no. 58 (2019): 6219.

Activating the Intrinsic Pathway of Apoptosis Using BIM BH3 Peptides Delivered by Peptide Amphiphiles with Endosomal Release

Schnorenberg, M.R., Bellairs, J.A., Samaeekia, R., Acar, H., Tirrell, M.V. and LaBelle, J.L., 2019. Activating the Intrinsic Pathway of Apoptosis Using BIM BH3 Peptides Delivered by Peptide Amphiphiles with Endosomal Release. Materials, 12(16), p.2567.

Synthesis and Purification of Homogeneous Lipid-Based Peptide Nanocarriers by Overcoming Phospholipid Ester Hydrolysis

Schnorenberg, M. R., Yoo, S. P., Tirrell, M. V., LaBelle. Synthesis and Purification of Homogeneous Lipid-Based Peptide Nanocarriers by Overcoming Phospholipi. ACS Omega. 2018. Vol. 3, Pg. 14144-14150.

Self-assembling peptide-based building blocks in medical applications

H. Acar, S. Srivastava, E. J. Chung, M. R. Schnorenberg, J. C. Barrett, J. L. LaBelle, M. Tirrell. Self-assembling peptide-based building blocks in medical applications. Advanced Drug Delivery Reviews. 2016.