Esser-Kahn Group

We use chemistry and materials to answer unique questions across different fields. Our motto: chemistry everywhere. Our tools live at the intersection of chemistry, biology, and material science. We are interested in questions like, what makes a good vaccine a good vaccine? Trying to answer this fundamental question with chemical tools led to our work in bottom up vaccine design.

We also wonder: what is the world going to do with all the carbon dioxide we are producing and how can we invent new approaches for capturing and releasing it? Natural systems have been solving this problem for billions of years. We look to biology for inspiration on how to understand the fundamentals of design in carbon capturing systems, mass exchange devices, and harnessing unused energy. These ideas are just our current interests. Please check out our website where we explain some of the projects in greater detail. Come in. Click around and understand: who we are, what we are interested in, and how we operate. We are always interested in a good question or a new concept. If you need a chemistry collaborator, or have a chemical question, contact us. We are very interested in solving problems that are interdisciplinary. Thanks for stopping by.

Principal Investigator

Aaron Esser-Kahn

aesserkahn@uchicago.edu

Mitigation of Hydrophobicity-Induced Immunotoxicity by Sugar Poly(orthoesters)

Sampa Maiti, Saikat Manna, Jingjing Shen, Aaron P. Esser-Kahn, and Wenjun Du. Mitigation of Hydrophobicity-Induced Immunotoxicity by Sugar Poly(orthoesters). Journal of the American Chemical Society. 2019.

Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional

Saikat Manna, William J. Howitz, Nathan J. Oldenhuis, Alexander C. Eldredge, Jingjing Shen, Fnu Naorem Nihesh, Melissa B. Lodoen, Zhibin Guan , and Aaron P. Esser-Kahn. Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional. ACS Central Science. 2018. Vol. 4 (8), Pg. 982-995.

Bio-inspired counter-current multiplier for enrichment of solutes

Kyle Brubaker, Armand Garewal, Rachel C. Steinhardt & Aaron P. Esser-Kahn. Bio-inspired counter-current multiplier for enrichment of solutes. Nature Communications. 2018. Vol. 9.

Toll-like Receptor Agonist Conjugation: A Chemical Perspective

Bob J. Ignacio, Tyler J. Albin, Aaron P. Esser-Kahn, and Martijn Verdoes. Toll-like Receptor Agonist Conjugation: A Chemical Perspective. Bioconjugate Chemistry. 2018.

Polyelectrolyte-Enrobed Cancer Cells in View of Personalized Immune-Therapy

Lien Lybaert, Keun Ah Ryu, Riet De Rycke, Alfred C. Chon, Olivier De Wever, Karim Y. Vermaelen, Aaron Esser-Kahn, and Bruno G. De Gees. Polyelectrolyte-Enrobed Cancer Cells in View of Personalized Immune-Therapy. Advanced Science. 2017. Vol. 4.

Cancer Cell Lysate Entrapment in CaCO3 Engineered with Polymeric TLR-Agonists: Immune-Modulating Mic

Lien Lybaert, Keun Ah Ryu, Lutz Nuhn, Riet De Rycke, Olivier De Wever, Alfred Chon, Aaron Esser-Kahn, and Bruno De Geest. Cancer Cell Lysate Entrapment in CaCO3 Engineered with Polymeric TLR-Agonists: Immune-Modulating Mic. Chemistry of Materials. 2017. Vol. 29, Pg. 4209-4217.

A Photoactivatable Innate Immune Receptor for Optogenetic Inflammation

Brittany Moser and Aaron Esser-Kahn. A Photoactivatable Innate Immune Receptor for Optogenetic Inflammation. ACS Chemical Biology. 2017. Vol. 12, Pg. 347-350.

Surface Coating of Nanoparticles Reduces Background Inflammatory Activity while Increasing Particle

Brittany Moser, Rachel Steinhardt, and Aaron Esser-Kahn. Surface Coating of Nanoparticles Reduces Background Inflammatory Activity while Increasing Particle. ACS Biomaterials. 2017. Vol. 3, Pg. 206-213.

Mechanically controlled radical polymerization initiated by ultrasound

Hemakesh Mohapatra, Maya Kleiman & Aaron Palmer Esser-Kahn. Mechanically controlled radical polymerization initiated by ultrasound. Nature Chemistry. 2017. Vol. 9, Pg. 135-139.

Immune Response Modulation of Conjugated Agonists with Changing Linker Length

Keun Ah Ryu, Katarzyna Slowinska, Troy Moore, and Aaron Esser-Kahn. Immune Response Modulation of Conjugated Agonists with Changing Linker Length. ACS Chemical Biology. 2016. Vol. 11, Pg. 3347-3352.

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