Faculty

Jun Huang

  • Assistant Professor of Molecular Engineering
  • Research and Scholarly Interests: Immunology, High Throughput Systems Biology Methods, Single-Molecule/Single-Cell Imaging Techniques
  • Websites: Huang Lab
  • Contact: huangjun@uchicago.edu
    773.702.3218
  • Assistant: Alicia Bearden-Mannie
  • Office Location:
    Eckhardt Research Center
    Room 371
    5640 South Ellis Avenue
    Chicago, IL 60637

Jun Huang received his MS in chemical engineering in 2007 and PhD in bioengineering in 2008 at the Georgia Institute of Technology.

Prof. Huang started his postdoctoral research in immunology in 2009 at Stanford University. He is a recipient of the prestigious NIH Pathway to Independence Award (K99/R00 program).

Huang Lab’s research focuses on quantitative study of the protective immune function of conventional T cells, the immunosuppressive properties of regulatory T cells and the cytolytic function of natural killer cells. Utilizing state-of-the-art single-molecule and single-cell imaging techniques, single-molecule biomechanical assays as well as high-throughput systems biology methods, Huang’s group carries out basic scientific research, focusing on molecular mechanisms and immune function of cells, as well as translational researches with the objective of developing immunotherapies for infectious diseases and cancer.

CD8+ T cells and NK cells: parallel and complementary soldiers of immunotherapy
Jillian Rosenberg, Jun Huang. CD8+ T cells and NK cells: parallel and complementary soldiers of immunotherapy. Current Opinion in Chemical Engineering. 2018. Vol. 19, Pg. 9-20.

Stable, small, specific, low-valency quantum dots for single-molecule imaging
Jungmin Lee, Xinyi Feng, Ou Chen, Moungi G Bawendi, Jun Huang. Stable, small, specific, low-valency quantum dots for single-molecule imaging. Nanoscale. 2018. Vol. 10.

The receptor repertoire and functional profile of follicular T cells in HIV-infected lymph nodes
Ben S. Wendel, Daniel Del Alcazar, Chenfeng He, Perla M. Del Río-Estrada, Benjamas Aiamkitsumrit, Yuria Ablanedo-Terrazas, Stefany M. Hernandez, Ke-Yue Ma, Michael Betts, Laura Pulido, Jun Huang, Phyllis A. Gimotty, Gustavo Reyes-Terán, Ning Jiang, Laura F. Su. The receptor repertoire and functional profile of follicular T cells in HIV-infected lymph nodes. Science Immunology. 2018.

Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells
Yunlong Zhao, Devin L. Harrison, Yuran Song, Jie Ji, Jun Huang, Enfu Hui. Publications. Cell Reports. 2018. Vol. 24, Pg. p379–390.e6.

Cathepsin-Mediated Cleavage of Peptides from Peptide Amphiphiles Leads to Enhanced Intracellular Pep
Handan Acar, Ravand Samaeekia, Mathew R Schnorenberg, Dibyendu K Sasmal, Jun Huang, Matthew V Tirrell, James L LaBelle. Cathepsin-Mediated Cleavage of Peptides from Peptide Amphiphiles Leads to Enhanced Intracellular Pep. Bioconjugate chemistry. 2017. Vol. 28, Pg. 2316-2326.

A myeloperoxidase-responsive and biodegradable luminescent material for real-time imaging of inflam.
Jiawei Guo, Hui Tao, Yin Dou, Lanlan Li, Xiaoqiu Xu, Qixiong Zhang, Juan Cheng, Songling Han, Jun Huang, Xiaodong Li, Xiaohui Li, Jianxiang Zhang. A myeloperoxidase-responsive and biodegradable luminescent material for real-time imaging of inflam.. Materials Today. 2017. Vol. 20, Pg. 493-500.

T cell co-stimulatory receptor CD28 is a primary target for PD-1–mediated inhibition
Enfu Hui, Jeanne Cheung, Jing Zhu, Xiaolei Su, Marcus J Taylor, Heidi A Wallweber, Dibyendu K Sasmal, Jun Huang, Jeong M Kim, Ira Mellman, Ronald D Vale. T cell co-stimulatory receptor CD28 is a primary target for PD-1–mediated inhibition. Science. 2017.

Single-molecule fluorescence resonance energy transfer in molecular biology
Dibyendu K Sasmal, Laura E Pulido, Shan Kasal, Jun Huang. Single-molecule fluorescence resonance energy transfer in molecular biology. Nanoscale. 2016. Vol. 8, Pg. 19928-19944.

Detection, phenotyping and quantification of antigen-specific T cells using a peptide-MHC dodecamer
J. Huang, X. Zeng, N. Sigal, P. J. Lund, L.F. Su, H. Huang, Chien, S. and M. M. Davis. Detection, phenotyping and quantification of antigen-specific T cells using a peptide-MHC dodecamer. Proceedings of the National Academy of Sciences. 2016.

Gamma delta T cells recognize haptens and mount a hapten-specific response
Xun Zeng, Christina Meyer, Jun Huang, Evan W Newell, Brian A Kidd, Yu-Ling Wei, Yueh-hsiu Chien. Gamma delta T cells recognize haptens and mount a hapten-specific response. Elife. 2014. Vol. 3, Pg. e03609.

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