Faculty

Aaron Esser-Kahn

Aaron Esser-Kahn was born and raised in Bloomfield Hills, Michigan. He may tell you that he is from Detroit, but he is not. He attended the Cranbrook educational community from grades K-12. He traveled west to study chemistry at the California Institute of Technology where he first developed a taste for boundary breaking research in the Tirrell Lab.

After completing his degree, he traveled north to Berkeley for a PhD in chemistry as part of the collaborative Chemical-Biology Program and the Francis Lab.

Our research interests lie at the intersection of biology, chemistry and materials science. We believe in using the tools from each discipline for the task at hand. Our group’s current research focuses on three projects that function as extensions of this philosophy. First, we are currently working toward microvascular thermal and gaseous exchange units. We are using knowledge derived from biology to replicate structures adapted for gas capture. Second, we are creating materials for reprogramming the immune system. Using tools from materials chemistry, we are creating polymer facades designed to rewire the immune system toward desired targets. Third, we are working towards creating synthetic tissue scaffolds.

Mitigation of Hydrophobicity-Induced Immunotoxicity by Sugar Poly(orthoesters)
Sampa Maiti, Saikat Manna, Jingjing Shen, Aaron P. Esser-Kahn, and Wenjun Du. Mitigation of Hydrophobicity-Induced Immunotoxicity by Sugar Poly(orthoesters). Journal of the American Chemical Society. 2019.

Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional
Saikat Manna, William J. Howitz, Nathan J. Oldenhuis, Alexander C. Eldredge, Jingjing Shen, Fnu Naorem Nihesh, Melissa B. Lodoen, Zhibin Guan , and Aaron P. Esser-Kahn. Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional. ACS Central Science. 2018. Vol. 4 (8), Pg. 982-995.

Bio-inspired counter-current multiplier for enrichment of solutes
Kyle Brubaker, Armand Garewal, Rachel C. Steinhardt & Aaron P. Esser-Kahn. Bio-inspired counter-current multiplier for enrichment of solutes. Nature Communications. 2018. Vol. 9.

Toll-like Receptor Agonist Conjugation: A Chemical Perspective
Bob J. Ignacio, Tyler J. Albin, Aaron P. Esser-Kahn, and Martijn Verdoes. Toll-like Receptor Agonist Conjugation: A Chemical Perspective. Bioconjugate Chemistry. 2018.

Polyelectrolyte-Enrobed Cancer Cells in View of Personalized Immune-Therapy
Lien Lybaert, Keun Ah Ryu, Riet De Rycke, Alfred C. Chon, Olivier De Wever, Karim Y. Vermaelen, Aaron Esser-Kahn, and Bruno G. De Gees. Polyelectrolyte-Enrobed Cancer Cells in View of Personalized Immune-Therapy. Advanced Science. 2017. Vol. 4.

Cancer Cell Lysate Entrapment in CaCO3 Engineered with Polymeric TLR-Agonists: Immune-Modulating Mic
Lien Lybaert, Keun Ah Ryu, Lutz Nuhn, Riet De Rycke, Olivier De Wever, Alfred Chon, Aaron Esser-Kahn, and Bruno De Geest. Cancer Cell Lysate Entrapment in CaCO3 Engineered with Polymeric TLR-Agonists: Immune-Modulating Mic. Chemistry of Materials. 2017. Vol. 29, Pg. 4209-4217.

A Photoactivatable Innate Immune Receptor for Optogenetic Inflammation
Brittany Moser and Aaron Esser-Kahn. A Photoactivatable Innate Immune Receptor for Optogenetic Inflammation. ACS Chemical Biology. 2017. Vol. 12, Pg. 347-350.

Surface Coating of Nanoparticles Reduces Background Inflammatory Activity while Increasing Particle
Brittany Moser, Rachel Steinhardt, and Aaron Esser-Kahn. Surface Coating of Nanoparticles Reduces Background Inflammatory Activity while Increasing Particle. ACS Biomaterials. 2017. Vol. 3, Pg. 206-213.

Mechanically controlled radical polymerization initiated by ultrasound
Hemakesh Mohapatra, Maya Kleiman & Aaron Palmer Esser-Kahn. Mechanically controlled radical polymerization initiated by ultrasound. Nature Chemistry. 2017. Vol. 9, Pg. 135-139.

Immune Response Modulation of Conjugated Agonists with Changing Linker Length
Keun Ah Ryu, Katarzyna Slowinska, Troy Moore, and Aaron Esser-Kahn. Immune Response Modulation of Conjugated Agonists with Changing Linker Length. ACS Chemical Biology. 2016. Vol. 11, Pg. 3347-3352.

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