Xuewen was raised in Cangzhou, a city on the east coast of China. He earned his BS degree in the Marine College at Shandong University. He moved to the US as a graduate student of IIT in 2009, where he built his knowledge in cell and molecular biology. He joined the University of Chicago in 2011. As the first employee of his previous lab, he saw how an empty laboratory became a highly productive academic fortress and how a fresh group grew up into a professional team. In 2017, he started a new career in data science as a part-time student in the Master of Science in Analytics program. He joined the Esser-Kahn Lab as the Research Manager in 2019. He contributes to the lab both with his experience in management and his knowledge in biology and data science.