Esser-Kahn Group

Saikat Manna

Saikat spent most of his childhood in a small city in the eastern part of India. He completed his bachelor's and master's in India, majoring in chemistry, and came to the United States with the hope of doing better science. He worked with Dr. Stuart Lindsay and Dr. Peiming Zhang on various projects during his PhD, primarily focusing on developing techniques to study multivalent interactions using AFM and SPR. He also worked on the synthesis of antibody-drug conjugates and cross-linking proteins to develop antibody mimics. Following this, he joined the University of California, Irvine as a postdoc to work on immune programming, primarily focusing on Inflammasome activation and developing multiple Pattern Recognition Receptor agonist conjugates. After a year in sunny California, he moved to Chicago along with the rest of the Esser-Kahn Lab. Having lived all his life in a tropical or subtropical desert climate, he is excited to be in the American Midwest.

PhD
Arizona State University, Tempe, Arizona; 2016
Professor Stuart Lindsay, Professor Peiming Zhang (co-advisors)
Applications of Multivalent Interactions in Recognition Imaging and Delivery of Therapeutics

MSc
Indian Institute of Technology, Kharagpur; 2010
Professor Manish Bhattacharjee

BSc
Calcutta University, India; 2008

Quote
“Science is organized common sense where many a beautiful theory was killed by an ugly fact.” —Thomas Huxley

Immune programming, mechanisms of immune activation, organic synthesis, bioconjugate chemistry.

Mitigation of Hydrophobicity-Induced Immunotoxicity by Sugar Poly(orthoesters)

Sampa Maiti, Saikat Manna, Jingjing Shen, Aaron P. Esser-Kahn, and Wenjun Du. Mitigation of Hydrophobicity-Induced Immunotoxicity by Sugar Poly(orthoesters). Journal of the American Chemical Society. 2019.

Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional

Saikat Manna, William J. Howitz, Nathan J. Oldenhuis, Alexander C. Eldredge, Jingjing Shen, Fnu Naorem Nihesh, Melissa B. Lodoen, Zhibin Guan , and Aaron P. Esser-Kahn. Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional. ACS Central Science. 2018. Vol. 4 (8), Pg. 982-995.

Applications of Immunomodulatory Immune Synergies to Adjuvant Discovery and Vaccine Development

Janine K. Tom, Tyler J. Albin, Saikat Manna, Brittany A. Moser, Rachel C. Steinhardt, Aaron P. Esser-Kahn. Applications of Immunomodulatory Immune Synergies to Adjuvant Discovery and Vaccine Development. Trends in Biotechnology.