Nihesh is a graduate student from Manipur, India and woks on the synthesis of chemical tools that help to understand the immune system better. Trained as an organic chemist, he is inspired by simple innovations and believes in loving chemistry even when it is not working. Nihesh is also an avid follower of Manchester United and enjoys cinema, food and comedy.
His research involves design and synthesis of adjuvants which targets multiple immune pathways similar to natural pathogen.
Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants
Brittany A. Moser, Yoseline Escalante-Buendia, Rachel C. Steinhardt, Matthew G. Rosenberger, Britteny J. Cassaidy, Nihesh Naorem, Alfred C. Chon, Minh H. Nguyen, Ngoctran T. Tran, and Aaron P. Esser-Kahn. Front Immunol. 2020; 11: 511513. doi: 10.3389/fimmu.2020.511513
Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional
Saikat Manna, William J. Howitz, Nathan J. Oldenhuis, Alexander C. Eldredge, Jingjing Shen, Fnu Naorem Nihesh, Melissa B. Lodoen, Zhibin Guan , and Aaron P. Esser-Kahn. Immunomodulation of the NLRP3 Inflammasome through Structure-Based Activator Design and Functional. ACS Central Science. 2018. Vol. 4 (8), Pg. 982-995.