A Texan born and raised, Matt Rosenberger attended the University of Texas at Austin and gained a passion for immunology while obtaining his BS in biomedical engineering. While his wardrobe still consists of mainly burnt orange, he has added some maroon gear and is happy to call the Esser-Kahn lab home. His research focuses on modulating the immune response in the context of vaccines.
Outside lab, he seeks to feed his avid sports fandom. He could watch basketball for hours and has adopted the Bulls as a replacement for his beloved Longhorns.
BS
The University of Texas at Austin, 2018
Advisor: Professor George Georgiou
Scientific hero
Paul Boyer
Matt’s work focuses on the immunoengineering of adjuvants for rational vaccine design. His research uses immunomodulators to fine tune the response to potent adjuvants. Particularly, he is curious about using these molecules to alter immunodominance, which would aid in combating rapidly mutating pathogens. While Matt’s currently working with a few previously proven modulators, he also assists in the discovery of new modulator/agonist adjuvant combinations. After multiple filtering steps with varying biological assays, this high throughput screening effort will ideally yield promising new adjuvants.
Small Molecule NF-κB Inhibitors as Immune Potentiators for Enhancement of Vaccine Adjuvants
Brittany A. Moser, Yoseline Escalante-Buendia, Rachel C. Steinhardt, Matthew G. Rosenberger, Britteny J. Cassaidy, Nihesh Naorem, Alfred C. Chon, Minh H. Nguyen, Ngoctran T. Tran, and Aaron P. Esser-Kahn. Front Immunol. 2020; 11: 511513. doi: 10.3389/fimmu.2020.511513
Increased Vaccine Tolerability and Protection via NF-κB Modulation
B. A. Moser, R. C. Steinhardt, Y. Escalante-Buendia, D. A. Boltz, K. M. Barker, B. J. Cassaidy, M.G. Rosenberger, S. Yoo, B. G. McGonnigal, and A. P. Esser-Kahn. Science Advances 09 Sep 2020: Vol. 6, no. 37, eaaz8700. doi: 10.1126/sciadv.aaz8700