Adam Weiss
Esser-Kahn Group

Adam Weiss

Adam was born and raised in Youngstown, Ohio, where he was first excited by academic research as a high school physics intern at Youngstown State University. He then attended the Ohio State University (Go Bucks!) where he double majored in chemistry and neuroscience. He performed research with Dr. Randy Nelson, and his undergraduate thesis focused on the physiological effects of chronic stress and dim light at night. Now, Adam is blending his interests in chemistry and immunology as a PhD co-advised by Aaron Esser-Kahn and Stuart Rowan.  Adam is a 2019-2020 and 2020-2021 NIH T32 Chemistry-Biology Interface training grant awardee. When not in the lab, Adam prefers to be outdoors, partaking in activities such as running, Scuba diving, camping, and concert-going in the Chicago area.  

Adam’s current work focuses on the use of modular polymer design to study the biophysical basis of NLRP3 inflammasome activation. Using high throughput polymer synthesis and rational molecular design, we hope to create a library of polymers that activate inflammasomes to better understand the mechanism of polymer-induced lysosomal rupture. This research will lead to the design of new vaccine adjuvants with enhanced safety profiles and controlled immune response profiles.

Site-specific antigen-adjuvant conjugation using cell-free protein synthesis enhances antigen presentation and CD8+ T-cell response

Weiss, A. M., Ajit, J., Albin, T. J., Kapoor, N., Maroju, S., Berges, A., … Esser-Kahn, A. P. (2021). Site-specific antigen-adjuvant conjugation using cell-free protein synthesis enhances antigen presentation and CD8+ T-cell response. Scientific Reports, 11(1).