Swartz Group: Publications Latest

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  1. Inherent biomechanical traits enable infective filariae to disseminate through collecting lymphatic vessels,” Kilarski WW, Martin C, Pisano M, Bain O, Babayan SA, Swartz MA. Nature Communications, 2019

  2. Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients,” Broggi MAS, Maillat L, Clement CC, Bordry N, Corthésy P, Auger A, Matter M, Hamelin R, Potin L, Demurtas D, Romano E, Harari A, Speiser DE, Santambrogio L, Swartz MA. Journal of Experimental Medicine, 2019

    Overview

    Identifying cancer biomarkers is of great interest for patient prognosis and monitoring. However, tumor-associated factors are diluted in blood and challenging to detect. We show that lymphatic exudate, accessible at the time of lymphadenectomy, is highly enriched in tumor-associated factors and therefore a promising source for biomarker discovery.

  3. “Nanoparticle Conjugation of Human Papillomavirus 16 E7-long Peptides Enhances Therapeutic Vaccine Efficacy against Solid Tumors in Mice,” Galliverti G, Tichet M, Domingos-Pereira S, Hauert S, Nardelli-Haefliger D, Swartz MA, Hanahan D, Wullschleger S. Cancer Immunology Research, 2018

  4. “Dorsal Ear Skin Window for Intravital Imaging and Functional Analysis of Lymphangiogenesis,” Kilarski WW, Güç E, Swartz MA. Methods in Molecular Biology, 2018

  5. “Lymphatic vessel density is associated with CD8+ T cell infiltration and immunosuppressive factors in human melanoma,” Bordry N, Broggi MAS, de Jonge K, Schaeuble K, Gannon PO, Foukas PG, Danenberg E, Romano E, Baumgaertner P, Fankhauser M, Wald N, Cagnon L, Abed-Maillard S, Maby-El Hajjami H, Murray T, Ioannidou K, Letovanec I, Yan P, Michielin O, Matter M, Swartz MA*, Speiser DE*. OncoImmunology, 2018

  6. Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanoma,” Fankhauser M*, Broggi MAS*, Potin L, Bordry N, Jeanbart L, Lund QW, Da Costa E, Hauert S, Rincon-Restrepo M, Tremblay C, Cabello E, Homicsko K, Michielin O, Hanahan D, Speiser DE and Swartz MA. Science Translational Medicine, 2017

    Overview

    Metastatic spread depends on lymphangiogenesis, and mediators of this pathway are targeted clinically for cancer treatment. We used mouse models of melanoma to show that blocking lymphangiogenesis actually disrupted recruitment of naïve T cells and subsequent antitumor immunity. Data from patients enrolled in clinical trials confirmed that indicators of lymphangiogenesis were associated with robust T cell responses. These findings have important implications for the use and predictions of response to immunotherapy.

  7. “Exploiting lymphatic vessels for immunomodulation: Rationale, opportunities, and challenges,” Maisel K, Sasso MS, Potin L, Swartz MA. Advanced Drug Delivery Reviews, 2017

  8. “Vaccine nanocarriers: Coupling intracellular pathways and cellular biodistribution to control CD4 vs CD8 T cell responses,” Rincon-Restrepo M, Mayer A, Hauert S, Bonner DK, Phelps EA, Hubbell JA, Swartz MA, Hirosue S. Biomaterials, 2017

  9. “Local induction of lymphangiogenesis with engineered fibrin-binding VEGF-C promotes wound healing by increasing immune cell trafficking and matrix remodeling,” Güç E, Briquez PS, Foretay D, Fankhauser MA, Hubbell JA, Kilarski WW, Swartz MA. Biomaterials, 2017

  10. Transcellular Pathways in Lymphatic Endothelial Cells Regulate Changes in Solute Transport by Fluid Stress,” Triacca V, Guc E, Kilarski WW, Pisano M, Swartz MA. Circulation Research, 2017

    Overview

    We show that solutes travel to lymphatic vessels both through and between lymphatic endothelial cells, and that this process is activately regulated by lymphatic endothelial cells.

  11. “Lymphatic vessels regulate immune microenvironments in human and murine melanoma,” Lund AW, Wagner M, Fankhauser M, Steinskog ES, Broggi MA, Spranger S, Gajewski TF, Alitalo K, Eikesdal HP, Wiig H, Swartz MA. The Journal of Clinical Investigation, 2016

  12. “Engineering opportunities in cancer immunotherapy,” Jeanbart L, Swartz MA. PNAS, 2015

  13. “Nanoparticle conjugation enhances the immunomodulatory effects of intranasally delivered CpG in house dust mite-allergic mice,” Ballester M, Jeanbart L, de Titta A, Nembrini C, Marsland BJ, Hubbell JA, Swartz MA. Scientific Reports, 2015

  14. “6-Thioguanine-loaded polymeric micelles deplete myeloid-derived suppressor cells and enhance the efficacy of T cell immunotherapy in tumor-bearing mice,” Jeanbart L, Kourtis IC, van der Vlies AJ, Swartz MA, Hubbell JA. Cancer Immunology, Immunotherapy, 2015

  15. “ADAM17 Promotes Motility, Invasion, and Sprouting of Lymphatic Endothelial Cells,” Mężyk-Kopeć R, Wyroba B, Stalińska K, Próchnicki T, Wiatrowska K, Kilarski WW, Swartz MA, Bereta J. PLoS One, 2015

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