January 11, 2018
11:00 AM - 12:00 PM
Speaker: Jason Cantor
Postdoctoral Fellow, Whitehead Institute for Biomedical Research
Title: "Environmental Impact on Human Cellular Metabolism"
We recently developed a new culture medium to reflect the polar metabolite composition of human plasma (human plasma-like medium; HPLM) and demonstrated that, relative to conventional media, it extensively alters the metabolic landscape of cultured cells. Through the use of HPLM, we also discovered an unforeseen example of metabolic regulation that would have been difficult to identify otherwise using existing model systems, and moreover, that influences the potency of a classic chemotherapeutic. Together with additional tools and methods we have developed, as well as with various strategies in functional genomics and metabolomics among others, we will continue our efforts to better understand how environmental factors impact the metabolic regulation and requirements of cancer and immune cells.