Event: IME Seminar: Abigail Knight


November 21, 2017
11:00 AM - 12:00 PM


ERC 201B


Speaker: Abigail Knight 
PhD, Arnold O. Beckman Postdoctoral Fellow, UCSB

Title: "Bioinspired Metal-Coordinating Materials"

Coordination of metal ions is critical to the structure and function of a variety of natural materials and allows a diverse array of capabilities currently unavailable to synthetic structures. This talk will highlight efforts towards mimicking two capabilities of natural materials: (1) the selective coordination of metal ions and (2) implementing metal ions to induce a morphological shift in self-assembled materials. Selective coordination is critical to the function of a variety of natural proteins, yet synthetic ligands with this capability are rare despite applications in heavy metal remediation, therapeutics, and recycling. A combinatorial platform implementing N-substituted glycine oligomers, or peptoids, was designed to identify motifs capable of chelating low concentrations of various metal ions in complex sample media. Amphiphilic marine siderophores have a more unique capability to undergo a morphological shift upon metal coordination. Inspired by these structures, coordinating peptide polymer amphiphiles were designed that undergo self-assembly directed by coordination geometry, adding to the toolbox of stimuli responsive materials.

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