de Pablo Group

Emre Sevgen

  • Graduate Student

Emre is from Istanbul, Turkey. He got his bachelor's degree from the University of Illinois at Urbana-Champaign in 2013, where he studied chemical engineering, bioengineering, and mathematics. He is currently pursuing a PhD in molecular engineering at the University of Chicago, co-advised by Professor Juan de Pablo and Professor Jeffrey Hubbell.

Crystallization-driven self assembly can drive formation of supramolecular assemblies into fibrils and spherical micelles with applications in immunology and drug delivery. A better understanding of the interplay between polymer physics and chemistry and their influence on important parameters such as drug release profile, particle size, stability, and transport/clearing can guide development of better nanoparticles. Emre's project includes all-atom molecular dynamics to elucidate self-assembly mechanisms and kinetics, development of nanocarriers for cancer immunotherapeutics based on those results, and investigation of basic polymer physics of fibrillar micelles using both experimental methods such as extensional flow in microfluidics as well as computational results.

Nanocrystalline Oligo(ethylene sulfide)-b-poly(ethylene glycol) Micelles: Structure and Stability

Sevgen, Emre, et al. "Nanocrystalline Oligo (ethylene sulfide)-b-poly (ethylene glycol) Micelles: Structure and Stability." Macromolecules 51.23 (2018): 9538-9546.

Hierarchical Coupling of First-Principles Molecular Dynamics with Advanced Sampling Methods

Sevgen, Emre, et al. "Hierarchical Coupling of First-Principles Molecular Dynamics with Advanced Sampling Methods." Journal of chemical theory and computation 14.6 (2018): 2881-2888.

Adaptive enhanced sampling by force-biasing using neural networks

Guo, Ashley Z., et al. "Adaptive enhanced sampling by force-biasing using neural networks." The Journal of chemical physics 148.13 (2018): 134108.

Ssages: Software suite for advanced general ensemble simulations

Sidky, Hythem, et al. "Ssages: Software suite for advanced general ensemble simulations." The Journal of chemical physics 148.4 (2018): 044104.

Molecular Structure of Canonical Liquid Crystal Interfaces

Sadati, Monirosadat, et al. "Molecular Structure of Canonical Liquid Crystal Interfaces." Journal of the American Chemical Society 139.10 (2017): 3841-3850.