Molecular engineering solutions for therapeutic peptide delivery

In a recent review by Acar et al., postdoctoral researchers from the Tirrell Group provide an account of current therapeutic peptide delivery strategies using self-assembled vehicles. Peptides (short amino acid sequences) are highly-selective therapeutics that naturally imitate the binding interfaces of proteins but require stabilization and protection to traverse complex biological barriers. This review was published in Chemical Society Reviews as part of a special issue featuring Supramolecular Medicine.

The review was written by former and current Tirrell group members Dr. Handan Acar (Professor at the University of Oklahoma), Dr. Jeffrey Ting (NIST-CHiMaD Postdoc Fellow), and Dr. Samanvaya Srivastava (Professor at the University of California Los Angeles), alongside Dr. James LaBelle (Professor of Pritzker School of Medicine), and Dr. Matthew Tirrell (Dean and Founding Pritzker Director of the Institute for Molecular Engineering).

From the Chemical Society Reviews website:

This themed issue in supramolecular medicine brings together leading experts working on supramolecular chemistry, biomaterials, molecular engineering, and pharmaceutical sciences, to review the recent progress in utilizing supramolecular nanostructures and materials to address emergent issues in health and disease, and to share their visions for future research directions in supramolecular design, non-covalent synthesis, biomaterial fabrication, and important medical applications.

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